High in vivo pDNA Liver-Selective Transfection
DLin-KC2-DMA facilitates high in vivo pDNA liver-selective transfection in animal models possibly due to its head group pKa and lipid tail structure. This is a great article about how chemical structure affects delivery. Read about it here.
"In vivo delivery of plasmid DNA by lipid nanoparticles: the influence of ionizable cationic lipids on organ-selective gene expression"